J4 ›› 2016, Vol. 13 ›› Issue (1): 143-149.doi: 10.1016/S1672-6529(14)60168-2
Electrospinning and Crosslinking of COL/PVA Nanofiber-microsphere Containing Salicylic Acid for Drug Delivery
Xiaoli Zhang1,2, Keyong Tang1, Xuejing Zheng1
- 1. College of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
2. Henan Key Laboratory of Functional Textile Materials, College of Textiles, Zhongyuan University of Technology, Zhengzhou 450007, China
Electrospinning and Crosslinking of COL/PVA Nanofiber-microsphere Containing Salicylic Acid for Drug Delivery
Xiaoli Zhang1,2, Keyong Tang1, Xuejing Zheng1
- 1. College of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
2. Henan Key Laboratory of Functional Textile Materials, College of Textiles, Zhongyuan University of Technology, Zhengzhou 450007, China
摘要：
Porous nanofiber-microsphere mats of collagen (COL)/polyvinyl alcohol (PVA) containing salicylic acid (SA) as model drug were prepared by electrospinning for the assessment of drug delivery system. The electrospun fibrous mats were crosslinked by UV-radiation or glutaraldehyde to weaken the degree of drug burst release and morphology damage when meeting water. The morphology and chemical structures of COL/PVA-SA electrospun fibers were characterized by SEM and FTIR. The crosslinking of UV-radiation did not destroy the morphology of COL/PVA-SA electrospun fibers in the crosslinking process, however, the crosslinking of glutaraldehyde did it. In vitro release studies showed that COL/PVA-SA electrospun fibers efficiently controlled the release of drugs by the crosslinking of UV-radiation for 4 h. The transport mechanism that controlled the release of drugs from electrospun mats was Fickian diffusion.