Journal of Bionic Engineering ›› 2021, Vol. 18 ›› Issue (4): 927-943.doi: 10.1007/s42235-021-0060-9
Reconstruction of Surface Porous PEEK Decorated with Strontium-doped Calcium Phosphate Coatings for Enhancing Osteogenic Activity
Chengcheng Liang1†, Xiong Xiong2†, Rongwei Cui2, Yuanxiao Hong1, Xin Liu1,
Guoru Zhao1, Lizi Ye3, Shuxin Qu1*
- 1. Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
2. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
3. Department of Pediatric Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
Reconstruction of Surface Porous PEEK Decorated with Strontium-doped Calcium Phosphate Coatings for Enhancing Osteogenic Activity
Chengcheng Liang1†, Xiong Xiong2†, Rongwei Cui2, Yuanxiao Hong1, Xin Liu1, #br#
Guoru Zhao1, Lizi Ye3, Shuxin Qu1*#br#
- 1. Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
2. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
3. Department of Pediatric Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
摘要： The aim of this study was to reconstruct surface porous structure with hundreds of micrometers and then bio-mineralize Sr-doped Calcium Phosphate (Sr-doped CaP) on Polyetheretherketone (PEEK) profile to enhance its bioactivity. A surface porous structure was prepared on PEEK profile by embedding and acid-etching of SiO2 particles as porogen (SP-PEEK). Then the Sr-doped CaP was further decorated on the porous surface after sulfonation, introduction of Sr-doped CaP crystal seeds and bio-mineralization in 1.5 times simulated body fluid (BSSP-PEEK-CaP/Sr). It was feasible to reconstruct the surface porous structure with hundreds of micrometers on PEEK profile by the present method without damaging its mechanical properties. The Sr-doped CaP crystal seeds effectively promoted the bio-mineralization of bio-inertness PEEK. All as-prepared PEEK did not inhibit the proliferation of cells. ALP of bio-mineralized groups was significantly increased than that of the other groups. The BSSP-PEEK-CaP/Sr obviously affected the morphology and promoted the adhesion and spreading of cells. As a result, the cyto-biocompatibity and bioactivity of PEEK were improved after bio-mineralization. Sr-doped CaP on PEEK most likely was beneficial for cells, which was associated with the increasing of the hydrophilicity on PEEK. This study provided a candidate method to improve the osteogenesis of PEEK implants.