Abstract: Mechanical loading constitutes a fundamental determinant in the process of bone remodeling. This modeling encompasses the incorporation of mechanical stimuli, the involvement of cellular and molecular constituents, as well as the utilization of sophisticated computational methodologies. Such an approach is imperative for forecasting bone behaviour across varying environmental conditions. In the present study, key findings from bone mechanobiology are reviewed, along with the possibility that Functionally Graded Materials (FGM) enhances osseointegration and lowers the stress-shielding effect during bone remodeling and compared to titanium, FGM improves periprosthetic bone remodeling. To summarise some of the most important findings from computational models of bone mechanobiology, explaining how modifications to the mechanical environment affect implant design, growth of bone, and bone response. The impact that changes related to the mechanical environment have on bone response is examined using computational models and methods such as surface microtopography to determine how an implant’s bone density has increased over time. This review focuses on the refinement of advanced simulation frameworks and their synergy with imaging technologies to strengthen model validation, ultimately resulting in better clinical outcomes in the context of bone health treatments.

Key words: Bone remodeling, Bone healing, Functionally graded materials, Implants, Osseointegration')">Bone remodeling, Bone healing, Functionally graded materials, Implants, Osseointegration