Abstract: Jaundice, common condition in newborns, is characterized by yellowing of the skin and eyes due to elevated levels of bilirubin in the blood. Timely detection and management of jaundice are crucial to prevent potential complications. Traditional jaundice assessment methods rely on visual inspection or invasive blood tests that are subjective and painful for infants, respectively. Although several automated methods for jaundice detection have been developed during the past few years, a limited number of reviews consolidating these developments have been presented till date, making it essential to systematically evaluate and present the existing advancements. This paper fills this gap by providing a thorough survey of automated methods for jaundice detection in neonates. The primary focus of the survey is to review the existing methodologies, techniques, and technologies used for neonatal jaundice detection. The key findings from the review indicate that image-based bilirubinometers and transcutaneous bilirubinometers are promising non-invasive alternatives, and provide a good trade-off between accuracy and ease of use. However, their effectiveness varies with factors like skin pigmentation, gestational age, and measurement site. Spectroscopic and biosensor-based techniques show high sensitivity but need further clinical validation. Despite advancements, several challenges including device calibration, large-scale validation, and regulatory barriers still haunt the researchers. Standardization, regulatory compliances, and seamless integration into healthcare workflows are the key hurdles to be addressed. By consolidating the current knowledge and discussing the challenges and opportunities in this field, this survey aims to contribute to the advancement of automatic jaundice detection and ultimately improve neonatal care.

Key words: Automated jaundice detection, Bilirubin estimation, Bilirubinometers, Computer-aided diagnosis, Hyperbilirubinemia, Jaundice, Neonates')">Automated jaundice detection, Bilirubin estimation, Bilirubinometers, Computer-aided diagnosis, Hyperbilirubinemia, Jaundice, Neonates