Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice

doi:10.1016/S1672-6529(13)60245-0

J4 ›› 2013, Vol. 10 ›› Issue (4): 514-521.doi: 10.1016/S1672-6529(13)60245-0

收稿日期:2013-01-13 修回日期:2013-09-12 出版日期:2013-09-09 发布日期:2013-10-10

Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice

Jinshu Ma, Zhenning Liu, Fang Wang, Qinghai Zhou, Chao Feng, Fan Li

1. Department of Pathogenobiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, P. R. China
2. Key Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun 130022, P. R. China
3. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, P. R. China
4. Department of Neurology, First Hospital, Jilin University, Changchun 130021, P. R. China

Received:2013-01-13 Revised:2013-09-12 Online:2013-09-09 Published:2013-10-10
Contact: Fan Li E-mail:fanli_liu@sina.com
About author:Jinshu Ma, Zhenning Liu, Fang Wang, Qinghai Zhou, Chao Feng, Fan Li

摘要/Abstract

关键词: biomaterial, poly-propylene carbonate, PPC, biodistribution

Abstract:

Biomaterials have attracted more attention from biomedical research in recent years. Yet there are still unmet demands for current biomaterials, such as the reduction of local inflammation of the implantation site. Poly-Propylene Carbonate (PPC), a polymer with ester bonds on CO2 backbone, degrades to CO2 and water, which are natural components of human body, yielding less inflammatory response than traditional biomaterials. However, the tensile strength and heat resistance properties of PPC are less ideal. In order to improve the properties of PPC, we have developed a new PPC (M-PPC), modified by mixing with Poly-3-Hydroxybutyrate (PHB). Here, we report the biodistribution profiles of PPC and M-PPC, their biocompatibility and toxicity. 125I-radiolabeled PPC and M-PPC were prepared and their biodistribution in Balb/c mice were investigated. Then acute systemic toxicity and haemolysis assays were conducted to study their toxicity and biocompatibility respectively. Results show that M-PPC has a good potential to be used as bone repair materials because it possesses typical biodistribution pattern in major organs, minimal toxicity and good biocompatibility.

Key words: biomaterial, poly-propylene carbonate, PPC, biodistribution

Jinshu Ma, Zhenning Liu, Fang Wang, Qinghai Zhou, Chao Feng, Fan Li. [J]. J4, 2013, 10(4): 514-521.

Jinshu Ma, Zhenning Liu, Fang Wang, Qinghai Zhou, Chao Feng, Fan Li. Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice[J]. J4, 2013, 10(4): 514-521.

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Preparation of a New Radiolabeled Biomaterial and Its Biodistribution in Mice

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