J4 ›› 2010, Vol. 7 ›› Issue (1): 1-5.doi: 10.1016/S1672-6529(09)60186-4
• 论文 • 下一篇
On the Social Behaviour of Cells
Andrei P. Sommer1, Dan Zhu1, Tim Scharnweber2, Hans-Joerg Fecht1,3
- 1. Institute of Micro and Nanomaterials, University of Ulm, 89081 Ulm, Germany
2. Institute for Biological Interfaces, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
3. Institute for Nanotechnology, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
On the Social Behaviour of Cells
Andrei P. Sommer1, Dan Zhu1, Tim Scharnweber2, Hans-Joerg Fecht1,3
- 1. Institute of Micro and Nanomaterials, University of Ulm, 89081 Ulm, Germany
2. Institute for Biological Interfaces, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
3. Institute for Nanotechnology, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
摘要：
Polystyrene Petri dishes are in use in hundreds of thousands of laboratories world wide. Cell culture experiments performed in them provide fundamental information in a wide range of applications, including but not limited to testing novel biomaterials and pharmaceuticals, and stem cell research. These experiments cost billions of dollars per year. In this study we report on a potential deficiency of polystyrene Petri dishes, possibly caused by an increase in interfacial pH under relevant culture conditions and affecting cell performance. We conclude that cell performance on Petri dishes could be improved by improving the Petri dishes. As a spin-off of our study we postulate the concept that cancer cells and stem cells are social. It is impossible to validate this concept on the basis of the model established in this paper. However, the coherence of our insights may encourage further study and lead to the development of a qualitative improvement of cell culture devices, including Petri dishes and culture flasks, to the identification of potential strategies for chemotherapy and chemoprevention that could suppress progression of metastasis, and to the establishment of improved settings for tissue engineering and stem cell research. An immediate recommendation of our study is to use chemically and biologically inert substrates for important cell culture experiments, for example, nanocrystalline diamond.