Journal of Bionic Engineering ›› 2021, Vol. 18 ›› Issue (4): 915-926.doi: 10.1007/s42235-021-0059-2
Magnetic Ganoderma Lucidum Spores (mGLS): A Novel Regulatable Targeted Drug Delivery System
Bin Han1,2,3, Zhankun Weng1,2*, Yuhan Wu3, Xin Zhao1,2, Jingmei Li3*, Qinhan Zhang1,2, Kaige Qu1,2, #br#
Bojian Liang4, Fenguo Zhou5, Guixia Liu5, Zuobin Wang1,2#br#
- 1. Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China
2. International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China
3. School of Life Sciences, Changchun University of Science and Technology, Changchun 130022, China
4. Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
5. School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, China
Magnetic Ganoderma Lucidum Spores (mGLS): A Novel Regulatable Targeted Drug Delivery System
Bin Han1,2,3, Zhankun Weng1,2*, Yuhan Wu3, Xin Zhao1,2, Jingmei Li3*, Qinhan Zhang1,2, Kaige Qu1,2, #br#
Bojian Liang4, Fenguo Zhou5, Guixia Liu5, Zuobin Wang1,2#br#
- 1. Ministry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturing, Changchun University of Science and Technology, Changchun 130022, China
2. International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun 130022, China
3. School of Life Sciences, Changchun University of Science and Technology, Changchun 130022, China
4. Department of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
5. School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, China
摘要： In the past decades, many materials have been studied as carriers for targeted drug delivery. However, there is a need for utilizable and selective carrier materials with few side effects. Here, the magnetic Ganoderma Lucidum Spores (mGLS) as a highly efficient targeted drug delivery carrier were explored. Then the regulatable targeted drug delivery system was verified by loading and releasing of the 5-Fluorouracil (5-FU). The results showed that the maximum of the loaded 5-FU reached 250.23 mg·g?1 in the mGLS. The cumulative release of the 5-FU for the drug delivery system could reach 80.11% and 67.14% in the PBS and HCl after 48 h, respectively. In addition, this system showed the good pharmacokinetic properties in vivo. After 12 h, the blood concentration in the 5-FU@mGLS group kept at 5.3 μg·mL?1 and was four times higher than that in the 5-FU group. In summary, the GLS as a natural microscale core-shell structures appears the striking application in carrier material for oral drug delivery.