Journal of Bionic Engineering ›› 2021, Vol. 18 ›› Issue (6): 1378-1390.doi: 10.1007/s42235-021-00115-7
Electrospun Scaff old of Collagen and Polycaprolactone Containing ZnO Quantum Dots for Skin Wound Regeneration
Pengfei Li 1, Liming Ruan 2, Ruofan Wang 1,2, Tianqi Liu 1, Gao Song 1, Xiaofei Gao 1, Guohua Jiang 1,3,4, Xiaoyan Liu 5
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1 School of Materials Science and Engineering , Zhejiang SciTech University , Hangzhou 310018 , China
2 Department of Dermatology , Beilun People’s Hospital of Ningbo City , Ningbo 315800 , China
3 Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering , Zhejiang Sci-Tech University , Hangzhou 310018 , China
4 Institute of Smart Biomedical Materials , Zhejiang Sci-Tech University , Hangzhou 310018 , China
5 Department of Dermatology , The 1st Affi liated Hospital of Zhejiang University , Hangzhou 310003 , China
Electrospun Scaff old of Collagen and Polycaprolactone Containing ZnO Quantum Dots for Skin Wound Regeneration
Pengfei Li 1, Liming Ruan 2, Ruofan Wang 1,2, Tianqi Liu 1, Gao Song 1, Xiaofei Gao 1, Guohua Jiang 1,3,4, Xiaoyan Liu 5
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1 School of Materials Science and Engineering , Zhejiang SciTech University , Hangzhou 310018 , China
2 Department of Dermatology , Beilun People’s Hospital of Ningbo City , Ningbo 315800 , China
3 Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering , Zhejiang Sci-Tech University , Hangzhou 310018 , China
4 Institute of Smart Biomedical Materials , Zhejiang Sci-Tech University , Hangzhou 310018 , China
5 Department of Dermatology , The 1st Affi liated Hospital of Zhejiang University , Hangzhou 310003 , China
摘要： Nanofi bers (NFs) have been widely used in tissue engineering such as wound healing. In this work, the antibacterial ZnO quantum dots (ZnO QDs) have been incorporated into the biocompatible poly (ε-caprolactone)/collagen (PCL/Col) fi brous scaff olds for wound healing. The as-fabricated PCL-Col/ZnO fi brous scaff olds exhibited good swelling, antibacterial activity, and biodegradation behaviors, which were benefi cial for the applications as a wound dressing. Moreover, the PCL-Col/ZnO fi brous scaff olds showed excellent cytocompatibility for promoting cell proliferation. The resultant PCL-Col/ZnO fi brous scaff olds containing vascular endothelial growth factor (VEGF) also exhibited promoted wound-healing eff ect through promoting expression of transforming growth factor-β (TGF-β) and the vascular factor (CD31) in tissues in the early stages of wound healing. This new electrospun fi brous scaff olds with wound-healing promotion and antibacterial property should be convenient for treating wound healing.