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An Adaptive Hybrid SCSOWOA Algorithm for Generalized Multi-level Thresholding in Multi-organ Medical Image Segmentation
M. Faruk Şahin, Farzad Kiani
Journal of Bionic Engineering. 2026, 23 (2):
1240-1262.
DOI: 10.1007/s42235-025-00832-3
This study presents a novel hybrid optimization model that combines the
complementary aspects of Sand Cat Swarm Optimization (SCSO) and Whale
Optimization Algorithm (WOA) to solve the multi-level image thresholding
problem. The proposed approach utilizes an adaptive two-stage mechanism
that balances the high exploration capacity of SCSO with the
concentrated local search capability of WOA, aiming to maximize
inter-class variance in the histogram-based thresholding process.
Various experiments are conducted on lung cancer, prostate, and mixed
medical image datasets. Results demonstrate that modified SCSOWOA
achieves superior performance across all datasets. For LC25000, it
attains PSNR 27.9453 dB, SSIM 0.9340, FSIM 0.9542, Dice coefficient
0.8901, and Jaccard index 0.8034 at T?=?12. For prostate, PSNR reaches
28.3965 dB, SSIM 0.7532, FSIM 0.8170, Dice 0.9215, and Jaccard 0.8593.
In the MSD dataset, SCSOWOA achieves PSNR 29.3244 dB, SSIM 0.7118, FSIM
0.7562, Dice 0.8901, and Jaccard 0.8034, indicating consistent
performance across diverse organs and modalities. The method also
demonstrates high computational efficiency, with an average execution
time of 1.3221 s, offering up to 40% speed improvement over conventional
metaheuristics such as PSO and GWO. Overall, proposed method provides
high-accuracy, low-variance, and computationally efficient segmentation,
preserving both structural and perceptual fidelity. These results
confirm the method’s robustness, generalizability, and practical
applicability for AI-assisted diagnostic systems across
histopathological and medical imaging contexts, balancing precision,
structural preservation, and speed for real-world clinical deployment.
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