Abstract: Tissue engineering holds promise in developing materials for biological applications, such as bone tissue repair. This study focuses on bioabsorbable and biocompatible polymers like Poly(L-lactic acid) (PLLA), Polyurethane (PU), and Polycaprolactone (PCL), along with nanohydroxyapatite (nHA), an essential osteoconductive ceramic. The main objective was the development and characterization of scaffolds obtained by Rotary Jet Spinning (RJS) using PLLA, PU, and PCL incorporated with nHA, for bone-related applications. The resulting scaffolds exhibited uniform fiber morphology and a rough surface, ideal for effective bone-tissue interaction. The crystallinity indicated the scaffolds’ bioactivity by apatite deposition in simulated body fluid. In addition, in vitro biological assays using preosteoblastic cells showed the biocompatibility of cells based on cell viability and adhesion parameters on the scaffolds. The results underscore the capacity of scaffolds incorporating nHA to promote both cell proliferation and osteoconduction, which are key elements essential for achieving effective bone regeneration.

Key words: Bone repair, Centrifugal spinning, Hydroxyapatite, Rotary jet spinning, Tissue engineering')">Bone repair, Centrifugal spinning, Hydroxyapatite, Rotary jet spinning, Tissue engineering