Abstract: This review article presents a comprehensive overview of emerging technologies in bone tissue engineering (BTE). This rapidly advancing field addresses the challenges of bone defects and injuries beyond traditional treatments like autografts and allografts. The study highlights the integration of 3D bioprinting, stem cell therapy, gene therapy, biomaterials, nanotechnology, and computational modeling as transformative approaches in BTE. Developing biomimetic scaffolds, advanced bio-inks, and composite nanomaterials has enhanced seaffold design, improving mechanical properties and biocompatibility. Innovatiohs in gene therapy and bioactive molecule delivery are showcased for their ability to modulate cellular behavior and enhance osteogenesis. Stem cell-based therapies leverage the regenerative potential of mesenchymal stem cells, facilitating tissue integration and functional restoration. Computational tools, including finite element analysis　(FEA) and agent-based modelling, aid in the optimization of scaffold design, predicting mechanical responses and biological behaviors. Despite notable progress, signifieant challenges, such as achieving reliable vascularization, sealable manu-facturing of engineered constructs, and effective clinical translation, remain substantial barriers to widespread adoption.　Future research efforts focused on refining these technologies are vital for translating innovative strategies into elinical practice, paving the way for personalized regenerative solutions in bone repair.

Key words: 3D printing')">3D printing, Biomaterials, Nanotechnology, Gene therapy, Bone tissue engineering