Abstract: This article reviews recent advancements, innovative strategies, and the key challenges in Drug Delivery Systems (DDS)　for bone regeneration, focusing on tissue engineering. It highlights the limitations of current surgical interventions forbone regeneration, particularly autogenic bone grafts, and discusses the exploration of alternative materials and methods, including allogeneic and xenogeneic bone grafts, synthetic materials, and biodegradable polymers. The objective is to provide a comprehensive understanding of how contemporary DDS can be optimized and integrated with tissue engineering approaches for more effective bone regeneration therapies. The review explained the mechanisms through which DDS enhance bone repair processes, identifies critical factors influencing their efficacy and safety, and offers an overview of current trends and future perspectives in the field. It emphasizes the need for advanced strategies in bone regeneration that focus on precise control of DDS to address bone conditions such as osteoporosis, trauma, and genetic predispositions leading to fractures.

Key words: Drug delivery')">Drug delivery, Bone regeneration, Bone repair, Scaffold