Journal of Bionic Engineering ›› 2022, Vol. 19 ›› Issue (1): 188-196.doi: 10.1007/s42235-021-00109-5
• • 上一篇
Albumin‑based Theranostic Nanosystem for Drug Controlled Release and Magnetic Resonance Imaging Guided Therapy
Qiaoying Wang1, Jiali Cai2, Zihan Xu2, Shihui Huang2, Ruiping Zhou3, Zhiyong Wang2,3
- 1 Leshan Vocational and Technical College, Leshan 614000, China 2 Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Materials Science and Engineering, Center for Functional Biomaterials, Sun Yat-sen University, Guangzhou 510275, China 3 Department of stomatology, Shenzhen Yantian District People’s Hospital, Shenzhen 518081, China
Albumin‑based Theranostic Nanosystem for Drug Controlled Release and Magnetic Resonance Imaging Guided Therapy
Qiaoying Wang1, Jiali Cai2, Zihan Xu2, Shihui Huang2, Ruiping Zhou3, Zhiyong Wang2,3
- 1 Leshan Vocational and Technical College, Leshan 614000, China 2 Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Materials Science and Engineering, Center for Functional Biomaterials, Sun Yat-sen University, Guangzhou 510275, China 3 Department of stomatology, Shenzhen Yantian District People’s Hospital, Shenzhen 518081, China
摘要： Chemotherapy is still a kind of important strategy for cancer treatment, but lacking efective delivery system limits the therapeutic outcome. Owing to the excellent biocompatibility, albumin has been employed as drug vehicle; however, it has to face complicated synthesis procedures and still needs an efective technology for the drug delivery evaluation. In this study, a facile method was utilized to prepare a protein-based theranostic system through the self-assembly of albumins with small molecules and drugs; furthermore, the paramagnetic divalent manganese ions were conjugated on the surface of the nanocomposite through a coordination bond and carried out the magnetic resonance imaging. This nanosystem with a stable structure exhibited about 80 nanometer size and 7.7 [Mn] mM-1S-1 T1 relaxivity; moreover, the pH-sensitive drug releasing property and the imaging function empower it with theranostic cancer therapy. Moreover, the nanocomposites efectively entered into the cancer cells and showed superior antitumor ability; and these treated cells exhibited signifcant T1 signal. These results suggested that the albumin-based nanosystem is a novel chemotherapy drug delivery vehicle and a promising candidate for magnetic resonance imaging.