Journal of Bionic Engineering ›› 2025, Vol. 22 ›› Issue (2): 562-573.doi: 10.1007/s42235-025-00650-7
Dual-responsive Tumbleweed-inspired Soft Robot Based on Poly(N‑isopropylacrylamide) and MoS2 for Targeted Drug Delivery in Stomach
Xiangyu Teng1; Shuxuan Yu1; Zezheng Qiao1; Zhixing Ge2; Wenguang Yang1
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1 School of Electromechanical and Automotive Engineering,Yantai University, Yantai 264005, China
2 Department of Biomedical Engineering, National Universityof Singapore, Singapore 999002, Singapore
Dual-responsive Tumbleweed-inspired Soft Robot Based on Poly(N‑isopropylacrylamide) and MoS2 for Targeted Drug Delivery in Stomach
Xiangyu Teng1; Shuxuan Yu1; Zezheng Qiao1; Zhixing Ge2; Wenguang Yang1
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1 School of Electromechanical and Automotive Engineering,Yantai University, Yantai 264005, China
2 Department of Biomedical Engineering, National Universityof Singapore, Singapore 999002, Singapore
摘要： In recent years, robots used for targeted drug delivery in the stomach have received extensive attention. Inspired by tumbleweeds, we have designed a dual-responsive soft robot based on poly(N-isopropylacrylamide) and MoS2. Under the action of an adjustable magnetic field, it can achieve steady motion at a frequency that allows it to move up to 35 mm/s, demonstrating high flexibility and controllability. It can also roll along a predetermined path, traverse mazes, climb over obstacles, among other functions. In addition, by harnessing the photothermal conversion effect of MoS2, the robot can be opened and closed using light, enabling controlled drug release. Targeted drug delivery is achieved in a gastric model using our designed soft robot, marking a significant clinical advancement expected to revolutionize future medical treatments and enhance the efficacy of drug therapy.