Abstract: As a key structure between Cells and Extracellular Matrix (ECM), Basement Membranes(BM)play an irreplaceable role in maintaining tissue morphology and physiological functions, and its damage is closely related to the pathological process of many organ diseases. In recent years, bionic Artificial Basement Membranes (ABM), as innovative biomaterials, have received extensive attention in tissue engineering and regenerative medicine. In the present review, we systematically sorted out the distribution characteristics of BM in various tissues and organs of the human body, and then deeply analyzed the intrinsic connection between their fine structure and physiological functions. The pathological mechanisms of BM damage and related diseases (e.g., kidney disease, pulmonary fibrosis, etc.) have been described on this basis. Then, from the perspective of material science design, the latest research progress of ABM in the direction of structural biomimetic construction, functional component optimization, and bioactive modification has been comprehensively reviewed. Finally, the potential development of biomimetic ABM in clinical translational applications has been discussed concerning the technical bottlenecks in the current research. This review aims to promote the applications of ABM in biomedical fields and provide new solutions for tissue repair and regeneration.

Key words: Basement membrane')">Basement membrane, Bionic artificial basement membrane, Collagen IV, Laminin, Nanofibers