Abstract: Marine biofouling is the undesired attachment and formation of marine organisms on surfaces, which adversely affects ship maintenance, economic costs, and ecosystem health. Despite remarkable advancements in antifouling coatings, developing formulations that simultaneously achieve environmental benign and high antifouling performances remains a critical challenge. Herein, drawing inspiration from the natural antifouling mechanisms including the superhydrophobicity of lotus leaves and biochemical defense of coral mucus, we developed a Superhydrophobic Antifouling Coating (SHAC) incorporating coral mucus-derived agents. This biomimetic design synergistically integrates physical anti-adhesion of superhydrophobic surfaces with chemical repellency of antifouling agents, yielding outstanding antifouling performance. The SHAC demonstrates remarkable durability (withstanding 100 abrasion cycles), sustained superhydrophobicity (contact angle?>?150°), and outstanding antifouling efficacy (92% bacterial and 96% algal inhibition). Marine field tests demonstrate significant reduction in fouling organism attachment over 30 days. Our work presents an eco-friendly and high-performance solution to marine biofouling, bridging the gap between sustainability and effectiveness in antifouling technology.

Key words: Marine biofouling, Antifouling coating, Coral mucus, Physicochemical antifouling')">Marine biofouling, Antifouling coating, Coral mucus, Physicochemical antifouling