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Journal of Bionic Engineering ›› 2022, Vol. 19 ›› Issue (3): 737-751.doi: 10.1007/s42235-022-00152-w

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Current Status and Outlook of Porous Zn-based Scaffolds for Bone Applications: A Review

Abdul Hakim Md Yusop1, Mokhamad Fakhrul Ulum2, Ahmed Al Sakkaf3, Hadi Nur1,4   

  1. 1 Center for Sustainable Nanomaterials, Ibnu Sina Institute for Scientifc and Industrial Research, Universiti Teknologi Malaysia, 81310 Johor Bharu, Malaysia  2 Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor 16680, Indonesia  3 School of Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bharu, Malaysia  4 Center of Advanced Materials for Renewable Energy (CAMRY), Universitas Negeri Malang, Malang 65145, Indonesia
  • Received:2021-04-19 Revised:2021-12-24 Accepted:2021-12-29 Online:2022-05-10 Published:2022-05-05
  • Contact: Hadi Nur E-mail:hadinur.fmipa@um.ac.id
  • About author:Abdul Hakim Md Yusop1, Mokhamad Fakhrul Ulum2, Ahmed Al Sakkaf3, Hadi Nur1,4

Abstract: Over the past 5 years, many works have been performed to reveal the potentials of Zinc (Zn)-based materials as temporary bone scaffolds with the expectation that their emergence could address some of the main concerns associated with magnesium- and iron-based materials. Thanks to the emerging Additive Manufacturing (AM) technology, it facilitates the optimization of the design and production of topological porous Zn-based materials suited for bone scaffolds. Since the studies on the porous Zn-based scaffolds are on the rise, we provide the most current progress in the development of porous Zn-based scaffolds for bone applications. The impacts of recently developed topological design from the AM as well as the advanced dynamic-flow corrosion on their corrosion, mechanical properties, and in vitro biocompatibility are also presented. Plus, we identify a number of research gaps and the challenges encountered in adopting porous Zn-based scaffolds for orthopedic applications and suggest some promising areas for future research.

Key words: Porous Zn, Corrosion, Mechanical properties, In vitro biocompatibility, Additive manufacturing