Abstract: 3D porous scafold could provide suitable bone-like structure for cell adhesion and proliferation; however, surgical suffering from large volume implantation is a great challenge for patients. In this study, a shape programmable porous poly(ε-caprolactone) (PCL)-based polyurethane scafold with memory efect was synthesized via gas foaming method, using Citrate modifed Amorphous calcium Phosphate (CAP) as bioactive factor. The bending experiments indicated that the scafolds achieved excellent shape-memory efect, which could be infuenced by particle weight content. In vitro mineralization results suggested that the deposition of hydroxyapatite was promoted by scafolds. Additionally, cell assay showed that composite scafolds presented good cell toxicity and osteogenicity by the diferentiation of rat Mesenchymal Stem Cells (rMSCs) into the osteogenic lineage. In the model of rat cranial implantation, the reparative tissue covered the defect site and bone-like structure deposited on the scafold due to the formation of new bones. In summary, the porous smart shape-memory composite scafolds could be a potential candidate in future distinctive bone repair applications.

Key words: Porous scafolds, Bone repair, Shape-memory polyurethane, Amorphous calcium phosphate, Biocompatibility