Journal of Bionic Engineering ›› 2025, Vol. 22 ›› Issue (6): 3140-3153.doi: 10.1007/s42235-025-00798-2
Rotary Jet Spun Semicrystalline Polymers Containing Nanohydroxyapatite Increase Bioactivity and Cell Adhesion for Bone Applications
Isabella Caroline Pereira Rodrigues1, Jaiber Humberto Rodriguez Llanos2, Lúcia Helena Pereira Mendonça1, Karina Danielle Pereira3, Augusto Ducati Luchessi3, Éder Sócrates Najar Lopes1, Laís Pellizzer Gabriel1,2
- 1 Faculdade de Engenharia Mecanica, Universidade Estadualde Campinas, R. Mendeleyev, 200 - Cidade Universitária,Campinas Zip Code 13083-860, S?o Paulo, Brazil 2 Faculdade de Ciências Aplicadas, Universidade Estadual deCampinas, Limeira Zip Code 13484-350, S?o Paulo, Brazil 3 Laboratório de Biotecnologia InPhyto, Faculdade de CiênciasAplicadas, Universidade Estadual de Campinas,Limeira Zip Code 13484-350, S?o Paulo, Brazil
Rotary Jet Spun Semicrystalline Polymers Containing Nanohydroxyapatite Increase Bioactivity and Cell Adhesion for Bone Applications
Isabella Caroline Pereira Rodrigues1, Jaiber Humberto Rodriguez Llanos2, Lúcia Helena Pereira Mendonça1, Karina Danielle Pereira3, Augusto Ducati Luchessi3, Éder Sócrates Najar Lopes1, Laís Pellizzer Gabriel1,2
- 1 Faculdade de Engenharia Mecânica, Universidade Estadualde Campinas, R. Mendeleyev, 200 - Cidade Universitária,Campinas Zip Code 13083-860, São Paulo, Brazil 2 Faculdade de Ciências Aplicadas, Universidade Estadual deCampinas, Limeira Zip Code 13484-350, São Paulo, Brazil 3 Laboratório de Biotecnologia InPhyto, Faculdade de CiênciasAplicadas, Universidade Estadual de Campinas,Limeira Zip Code 13484-350, São Paulo, Brazil
摘要： Tissue engineering holds promise in developing materials for biological applications, such as bone tissue repair. This study focuses on bioabsorbable and biocompatible polymers like Poly(L-lactic acid) (PLLA), Polyurethane (PU), and Polycaprolactone (PCL), along with nanohydroxyapatite (nHA), an essential osteoconductive ceramic. The main objective was the development and characterization of scaffolds obtained by Rotary Jet Spinning (RJS) using PLLA, PU, and PCL incorporated with nHA, for bone-related applications. The resulting scaffolds exhibited uniform fiber morphology and a rough surface, ideal for effective bone-tissue interaction. The crystallinity indicated the scaffolds’ bioactivity by apatite deposition in simulated body fluid. In addition, in vitro biological assays using preosteoblastic cells showed the biocompatibility of cells based on cell viability and adhesion parameters on the scaffolds. The results underscore the capacity of scaffolds incorporating nHA to promote both cell proliferation and osteoconduction, which are key elements essential for achieving effective bone regeneration.