Journal of Bionic Engineering ›› 2022, Vol. 19 ›› Issue (1): 167-178.doi: 10.1007/s42235-021-00125-5
• • 上一篇
Biocompatible Poly(ε‑caprolactone)‑based Shape‑memory Polyurethane Composite Scafold with Bone‑induced Activity
Kun Luo1, Li Wang1, Xiaohu Chen1, Xiyang Zeng1, Shiyi Zhou1, Peicong Zhang1, Junfeng Li1
- 1 College of Materials, Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China
Biocompatible Poly(ε‑caprolactone)‑based Shape‑memory Polyurethane Composite Scafold with Bone‑induced Activity
Kun Luo1, Li Wang1, Xiaohu Chen1, Xiyang Zeng1, Shiyi Zhou1, Peicong Zhang1, Junfeng Li1
- 1 College of Materials, Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China
摘要： 3D porous scafold could provide suitable bone-like structure for cell adhesion and proliferation; however, surgical suffering from large volume implantation is a great challenge for patients. In this study, a shape programmable porous poly(ε-caprolactone) (PCL)-based polyurethane scafold with memory efect was synthesized via gas foaming method, using Citrate modifed Amorphous calcium Phosphate (CAP) as bioactive factor. The bending experiments indicated that the scafolds achieved excellent shape-memory efect, which could be infuenced by particle weight content. In vitro mineralization results suggested that the deposition of hydroxyapatite was promoted by scafolds. Additionally, cell assay showed that composite scafolds presented good cell toxicity and osteogenicity by the diferentiation of rat Mesenchymal Stem Cells (rMSCs) into the osteogenic lineage. In the model of rat cranial implantation, the reparative tissue covered the defect site and bone-like structure deposited on the scafold due to the formation of new bones. In summary, the porous smart shape-memory composite scafolds could be a potential candidate in future distinctive bone repair applications.